Significance of Receptor Mobility in Multivalent Binding on Lipid Membranes

Numerous key biological processes rely on the concept of multivalency, where ligands achieve stable binding only upon engaging multiple receptors. These processes, like viral entry or immune synapse formation, occur diffusive cellular membrane. One crucial, yet underexplored aspect multivalent is mobility coupled Here, we discuss consequences in from four perspectives: (I) The facilitation receptor recruitment by ligand due to their diffusivity prior binding. (II) effects preassembly, which allows local accumulation. (III) changes formation receptor/ligand complex. (IV) lipid environment surrounding engaged We demonstrate how understanding essential for fully unravelling principles membrane leading further development studies interactions, and guide design new generations ligands.